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Blood flow and vascular permeability mapping in diabetic retinopathy

Session Date
ENGR 499-03
5/21 - 7/13/2018


In this undergraduate research immersion-individual based course, students will be exposed to modern aspects of dynamic contrast enhanced imaging: including an introduction to technological advancements in system development, image reconstruction, and data analysis. There will be an emphasis on quantitative hemodynamic and vascular permeability imaging approaches based on tracer kinetic modeling of systemically administered contrast agents. In Summer 2015, the student will be asked to develop and implement a methodology of estimating choroidal blood flow in the eye. The back of the eye is made up of two layers: the retina and the choroid. Conventional fluorescein based dynamic contrast enhanced ophthalmology can provide information only about the shallow retina layer; however, use of indocyanine green, which fluoresces at a more tissue penetrating wavelength, can offer insight into the hemodynamics of the deeper choroid layer. The student will specifically explore an approach to extract choroidal information out of indocyanine green data by accounting for retinal artifacts with conventional fluorescein maps. (CRN:33795)